Can PFAS exposure cause multiple myeloma?

Yes, PFAS can contribute to the development of blood cancers like multiple myeloma.

The most widely researched types of per- and polyfluoroalkyl substances (PFAS) are PFOA and PFOS. These two chemicals have been categorized by the International Agency for Research on Cancer as a "human carcinogen" and a "possible human carcinogen", respectively.

Similar to the mysterious causes of various cancers, the exact cause of multiple myeloma is not defined. Still, various mechanisms have been suggested for how PFAS chemicals can contribute to the development of cancer. These potential mechanisms include the following:

• At very high concentrations, PFAS can induce oxidative stress and cause DNA damage, including DNA strand breaks. Both of these changes can contribute to cancer development and progression.
• Other mechanisms are particularly relevant to multiple myeloma, which begins in plasma cells in the bone marrow. In a study presented at the 2022 American Association for Cancer Research Annual Meeting, it was found that PFAS chemicals accumulate in the bone marrow, alter the bone microenvironment, and promote both adipogenesis and osteoclastogenesis. These changes interfere with signaling pathways and may contribute to the survival of myeloma cells or other tumors.

Atraxia Law gives legal support to PFAS exposure victims

If you have been diagnosed with multiple myeloma after working at or living near a contaminated military base, chances are high that your condition is connected to PFAS exposure. If you are a military veteran, you are eligible for PFAS exposure claims and VA disability claims for multiple myeloma. If you are a family member of a veteran or a civilian resident who lived within one mile of a contaminated military base, you may also file PFAS exposure claims for multiple myeloma. Contact Atraxia Law to discuss your case further with our team.