Yes, exposure to PFAS is associated with liver cancer, particularly hepatocellular carcinoma (HCC). It has been shown that long-term exposure to PFAS disrupts lipid metabolism, causes chronic inflammation, damages DNA, and alters the microenvironment of liver tumors.
There is compelling evidence from animal studies. Bioaccumulation of PFAS in rodent livers has been shown to disrupt normal metabolic processes.
A laboratory study has shown that PFAS compounds induce oxidative stress in liver tissue and activate nuclear receptors that promote abnormal cancer cell growth.
Human epidemiological studies strongly support this connection. According to occupational studies, workers exposed to high PFAS levels have approximately twice the risk of developing liver cancer as those who are not exposed. Studies conducted in communities near PFAS-contaminated sites, such as Parkersburg, West Virginia, and Hoosick Falls, New York, report increased liver disease and cancer incidence.
Individuals with liver cancer have elevated levels of PFAS. High PFAS levels were linked to a 4.5-fold higher risk of hepatocellular carcinoma in a 2022 study, while PFOA levels were associated with liver cancer risk, particularly in men, in a large nested case-control study. A precursor to liver cancer is nonalcoholic fatty liver disease (NAFLD), which occurs when PFAS accumulate in the liver and disrupt lipid metabolism.
With more than 35 years of experience in toxic exposure litigation, our team can determine if PFAS exposure from contaminated military bases or other sources could qualify you for financial compensation for liver cancer. Evaluations are conducted mostly over the phone, and the process is simple. We will assign a specialized lawyer who has experience handling PFAS cases to those who qualify.