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How does Tepezza cause hearing loss and tinnitus?

Though the manufacturer has yet to fully describe and characterize the molecular, biochemical, and physiologic actions through which Tepezza treats thyroid eye disease (TED), it is believed that the mechanism by which Tepezza causes hearing loss and other hearing-related health damage is a result of this drug inhibiting the insulin-like growth factor-1 and the insulin-like growth factor-1 receptor pathway. What does this mean?

Tepezza infusion treatment acts like an inhibitor medication for insulin-like growth factor 1 receptor (IGF-IR), which receptor is crucial to protecting inner ear hair cells from:

The Tepezza warning label draws attention to hearing loss as an adverse effect in about 10% of the patients, but it was later shown in a study by Stanford University researchers and presented at the 2021 annual meeting of the Endocrine Society that this risk is significantly higher, reaching up to 65%.

Not all hearing loss issues resulting from Tepezza infusion treatment are reversible

Horizon Pharmaceutics, the manufacturer of Tepezza, claimed that hearing loss symptoms that occur as an adverse effect of the Tepezza infusion treatment are reversible and will disappear in a period of around three months after the last dose of the infusion was administered.

The study of the Stanford University researchers has shown, however, that while some of the symptoms are indeed reversible, this is not true for all of them and for all cases. Some of the symptoms not only did not improve over time but remained permanent.

Hearing issues linked to Tepezza infusion treatment

The most significant hearing-related health damages linked to the Tepezza infusion treatment are:

but other symptoms include:

If you have received several Tepezza infusions and you suffer as a consequence of any of the hearing loss symptoms listed above, contact our team at Atraxia Law, and we will help you determine your eligibility for filing a Tepezza claim to obtain compensation.

Atraxia Law can help you find out if you are eligible to file a Tepezza claim

The first step we will take is to determine if you are eligible to file a Tepezza claim. Should you qualify for filing a Tepezza claim, we will refer you to an attorney or law firm that best represents your case and maximizes your chances for compensation.

As is often the case for defective drug claims, Tepezza claims also have a statute of limitations. We recommend that you contact us as soon as your Tepezza-related hearing loss diagnosis is established.